Downloads

Tivdak patient resources

There are several useful tools available to help you while on Tivdak.

  • Tivdak Important Facts Icon
    Important Facts

    A short summary of key information about Tivdak.

    English

    Español

  • Tivdak Medication Guide Icon
    Medication Guide

    A brief overview of Tivdak.

    Download

  • Tivdak Patient Brochure Icon
    Patient Brochure

    An overview of Tivdak and what to expect from treatment.

    Download

  • Tivdak Eye Care Guide for Patients Icon
    Eye Care Guide for Patients

    A guide to eye care while on treatment.

    Download

  • Tivdak Discussion Guide Icon
    Tivdak Discussion Guide

    FAQs and topics to review with your care team.

    Download

  • Tivdak Wallet Card Icon
    Tivdak Wallet Card

    A card informing healthcare teams that you’re on Tivdak.

    Download

  • Tivdak Eye Drop Tracker Icon
    Eye Drop Tracker

    A tracker to help you stay on top of your eye drop schedule.

    Download

FAQs

Common questions about Tivdak

If your care team has prescribed you Tivdak, we're sure you have some questions. To help you learn more about Tivdak, please see some frequently asked questions below:

About Tivdak

  • What is Tivdak and why did my doctor prescribe it?

    In up to 60% of women with cervical cancer, their disease will spread to other parts of the body within 2 years after initial treatment. You may have heard the terms “recurrent” or “metastatic.” A cancer that went away after it was treated but has now come back is called “recurrent” cancer. When a cancer has spread from where it started to a distant part of the body, it is called “metastatic.” Your care team may refer to either recurrent or metastatic cancer as “advanced cancer.”

    When advanced cancer happens, treatments you have taken before for your cervical cancer may not be right for you anymore.

    Your doctor prescribed Tivdak because it is a prescription medicine used to treat adults with cervical cancer who have cancer that has returned or spread to other parts of the body, and have received chemotherapy that did not work or is no longer working.

  • How Tivdak is thought to work

    Based on lab results, Tivdak attaches to a special protein on the outside of the cancer cell called Tissue Factor and is absorbed into the cell. Once inside, Tivdak releases its cell-killing medicine.

    The special protein, Tissue Factor, is also present on normal cells. So, Tivdak can still harm normal cells and cause side effects.

  • How often will I need treatment?

    Tivdak is a 30-minute intravenous infusion (or IV) given every 3 weeks. Your doctor will decide how many treatments you need.

  • How long is each treatment?

    Work with your care team to help plan your infusion day. The actual infusion will take approximately 30 minutes with chair time of ~1 hour, which includes application of eye drops and cold packs. The full appointment may take more than an hour due to the pre-infusion check and paperwork.

Side Effects

  • What is the most important information I should know about Tivdak?

    • Tivdak can cause serious side effects, including eye problems. Eye problems are common with Tivdak, and can also be serious. Tivdak can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment with Tivdak

    • Your healthcare provider will send you to an eye specialist to check your eyes before you start treatment with Tivdak, before each dose of Tivdak, and as needed for any new or worsening signs and symptoms of eye problems

    • Your healthcare provider will prescribe 3 different types of eye drops before you start treatment with Tivdak. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider to reduce your risk of eye problems. You should use steroid eye drops before each infusion and as prescribed for 72 hours after each infusion. You should use vasoconstrictor eye drops right before each infusion. You should use lubricating eye drops throughout treatment and for 30 days after your last dose of Tivdak

    • Do not wear contact lenses throughout your treatment with Tivdak unless you are told to use them by your eye specialist

    For more information about eye problems, please see Important Facts about Tivdak.

  • What are the most serious side effects of Tivdak?

    • Eye problems are common with Tivdak, and can also be serious. Tivdak can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss

    • Peripheral neuropathy, or nerve problems that may cause numbness or tingling in your hands or feet or muscle weakness

    • Bleeding problems (hemorrhage). Signs or symptoms include: blood in your stools or black stools (looks like tar), blood in your urine, coughing up or vomiting blood, unusual vaginal bleeding, and any unusual or heavy bleeding

    • Lung problems that can lead to death. Signs or symptoms include: trouble breathing, shortness of breath, or cough

    Tell your healthcare provider right away if you get new or worsening signs or symptoms of any of the above serious side effects.

    For more information about possible side effects, please see Important Facts about Tivdak.

  • What are the most common side effects of Tivdak?

    The most common serious side effects were problems moving food and stool through your gut (ileus), bleeding, pneumonia, tingling or numbness in the hands and feet, sepsis, constipation, and fever.

    The most common side effects of Tivdak were:

    • Decreased red blood cell and white blood cell counts

    • Tiredness

    • Nausea

    • Numbness or tingling in your hands or feet, or muscle weakness (peripheral neuropathy)

    • Hair loss (alopecia)

    • Changes in kidney function blood tests

    • Nosebleed (epistaxis)

    • Dry eye

    • Eye problems (conjunctival disorders)

    • Bleeding (hemorrhage)

    • Abnormal blood clotting test results

    • Diarrhea

    • Rash

    These are not all the possible side effects of Tivdak. For more information see Important Facts about Tivdak.

  • If I think I have a side effect, how will I know when it’s time to call my care team?

    If you notice any new or worsening side effects, tell your care team right away.

  • Does a side effect mean I have to stop treatment?

    Your care team may need to change, pause, or stop your treatment if you have certain side effects. If you notice any new or worsening side effects, tell your care team right away.

  • Is there anything I can do to help reduce side effects?

    Tivdak Required Eye Care may help to reduce the risk of eye problems. Your care team may also recommend other medications to help combat possible side effects such as nausea, constipation, and/or diarrhea. Talk to your care team about any discomfort or side effects you are experiencing.

Eye Care

  • What do I do if I experience any eye problems?

    If you experience any new or worsening changes with your eyes or eye problems, call your care team. Your care team is there to help.

  • What happens if I forget my eye drops on the day of infusion?

    Forgetting your drops could delay your treatment. Remember to keep track of your drops so you don't run out. The best thing to do is to remember to bring all of your drops to your infusion appointment. Try setting a reminder or creating a checklist for yourself on the day of your appointment to help you remember. The Eye Drop Tracker can help you stay on top of your eye drop schedule.

  • Can I buy my eye drops over the counter?

    You will be prescribed 3 different types of eye drops. The vasoconstrictor and steroid drops will need to be filled by a pharmacist. You can purchase the lubricating drops over the counter. If the lubricating eye drops your care team recommended are not in stock, ask your pharmacist to recommend another.

Glossary

Common terms in advanced cervical cancer

Below are some common terms you may hear during your treatment with Tivdak.

  • Advanced cervical cancer

    A cancer that has come back after treatment or spread from the cervix to another area of the body.

  • Antibody

    A molecule in your body that recognizes foreign substances and helps your body destroy them.

  • Antibody-drug conjugate (ADC)

    An ADC delivers medicine directly to cancer cells, but can also harm normal cells and cause side effects.

  • Metastatic cancer

    A term for cancer that has spread to distant parts of the body.

  • Ophthalmologist

    A medical doctor who specializes in eye and vision care. An ophthalmologist diagnoses and treats all eye diseases, performs eye surgery, and prescribes and fits eyeglasses and contact lenses to correct vision problems.

  • Optometrist

    A healthcare professional who provides eye care ranging from sight testing and correction to the diagnosis, treatment, and management of vision changes. They also prescribe and fit eyeglasses and contact lenses to correct vision problems.

  • Protein

    Molecules that play many critical roles in our body. Proteins come in many shapes and sizes – an antibody is able to identify a unique protein on a cell.

  • Recurrent cancer

    A cancer that went away as a result of treatment, but has since returned.

Advocacy groups

Help is out there

When your previously-treated advanced cervical cancer comes back or spreads, it can be hard to know where to turn. There are a number of groups offering care and support throughout your experience.

These patient support groups are included as a reference for patients and caregivers. Their inclusion does not imply endorsement from the individual patient support groups listed.

  • Cervivor

    A cervical cancer awareness & support community, a learning tool, an advocacy resource, and an online retreat for healing, connecting, and thriving.

    cervivor.org

  • Foundation for Women’s Cancer

    A foundation dedicated to increasing research, education and awareness about gynecologic cancer risk, prevention, early detection and optimal treatment.

    foundationforwomenscancer.org

  • CancerCare

    A national organization that provides free case management, counseling, support groups, education, publications, and financial and co-payment assistance.

    cancercare.org

  • Cancer Support Community

    A worldwide network committed to ensuring that no one faces cancer alone by providing navigation, support, and resources through face-to-face, telephone, and online programming.

    cancersupportcommunity.org

  • Triage Cancer

    A nonprofit group that provides education on the practical and legal issues that may impact individuals diagnosed with cancer and their caregivers through free events, materials, and resources.

    triagecancer.org

  • National Cervical Cancer Coalition

    A grassroots organization that helps women, family members, and caregivers battle the personal issues related to cervical cancer and HPV, and advocates for cervical health in all women.

    nccc-online.org

Access Support and Assistance With Out-of-Pocket Costs

Seagen Secure® Patient Assistance Program Logo

The Seagen Secure® patient assistance program

Seagen Secure® is a personalized support program for people receiving or planning to receive Tivdak. Seagen Secure® may be able to help you if you don't have health insurance, aren't sure if your insurance will cover your Tivdak therapy, or if you need help paying out-of-pocket costs.a
When you, or your caregiver, call Seagen Secure®, you will speak with an Oncology Access Advocate, who can answer your questions and provide information about available resources and support.b

Call 855-4SECURE (855-473-2873) to learn how to enroll in Seagen Secure®.

aEligibility criteria apply. Financial support may be provided through third-party organizations that have their own eligibility criteria and enrollment processes. Seagen does not guarantee that enrollment will result in assistance and/or reimbursement.

bInformation provided by an Oncology Access Advocate is not intended to be a substitute for your healthcare provider. Discuss any questions you may have about your disease and your treatment with your healthcare team.

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about TIVDAK?

Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment.

Your healthcare provider will send you to an eye specialist to check your eyes before you start treatment with TIVDAK, before each dose of TIVDAK, and as needed for any new or worsening signs and symptoms of eye problems.

Your healthcare provider will prescribe 3 different types of eye drops before you start treatment with TIVDAK. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider to reduce your risk of eye problems:

  • You should use steroid eye drops before each infusion and as prescribed for 72 hours after each infusion.

  • You should use vasoconstrictor eye drops right before each infusion.

  • You should use lubricating eye drops throughout treatment and for 30 days after your last dose of TIVDAK.

Do not wear contact lenses throughout your treatment with TIVDAK unless you are told to use them by your eye specialist.

What are the possible side effects of TIVDAK?

Serious side effects of TIVDAK may include:

Peripheral neuropathy (nerve problems) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you have new or worsening numbness or tingling in your hands or feet or muscle weakness.

Bleeding (hemorrhage) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you get signs or symptoms of bleeding during treatment with TIVDAK including blood in your stools or black stools (looks like tar), blood in your urine, cough up or vomit blood, unusual vaginal bleeding, any unusual or heavy bleeding.

Lung problems. TIVDAK may cause severe or life-threatening inflammation of the lungs that can lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, or cough.

The most common side effects of TIVDAK include:

  • Decreased red blood cell and white blood cell counts

  • Tiredness

  • Nausea

  • Numbness or tingling in your hands or feet, or muscle weakness (peripheral neuropathy)

  • Hair loss (alopecia)

  • Nosebleed (epistaxis)

  • Eye problems (conjunctival disorders)

  • Bleeding (hemorrhage)

  • Changes in kidney function blood tests

  • Dry eye

  • Abnormal blood clotting test results

  • Diarrhea

  • Rash

Your healthcare provider may decrease your dose of TIVDAK, temporarily stop, or completely stop treatment if you have side effects.

What should I tell my healthcare provider before receiving TIVDAK?

Tell your healthcare provider about all your medical conditions, including if you:

  • have a history of vision or eye problems

  • have numbness or tingling in your hands or feet

  • have bleeding problems

  • have liver problems

  • are pregnant or plan to become pregnant, TIVDAK can harm your unborn baby.

  • are breastfeeding (nursing) or plan to breastfeed. It is not known if TIVDAK passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of TIVDAK

    Females who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with TIVDAK.

    • You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of TIVDAK.

    Males with female partners who are able to become pregnant:

    • You should use effective birth control during treatment and for 4 months after the last dose of TIVDAK

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking TIVDAK with certain other medicines may cause side effects.

These are not all the possible side effects of TIVDAK. Discuss side effects with your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.

Please see Important Facts about TIVDAK including IMPORTANT WARNING.

What is TIVDAK®?

TIVDAK is a prescription medicine used to treat adults with cervical cancer:

  • that has returned or has spread to other parts of the body, and

  • who have received chemotherapy that did not work or is no longer working

TIVDAK was FDA-approved based on a clinical study that measured how many patients had a tumor response and how long that response lasted. Continued approval is dependent on the results of an ongoing study to confirm the benefit of TIVDAK.

Important Safety Information

What is the most important information I should know about TIVDAK?

Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss.

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about TIVDAK?

Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment.

Your healthcare provider will send you to an eye specialist to check your eyes before you start treatment with TIVDAK, before each dose of TIVDAK, and as needed for any new or worsening signs and symptoms of eye problems.

Your healthcare provider will prescribe 3 different types of eye drops before you start treatment with TIVDAK. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider to reduce your risk of eye problems:

  • You should use steroid eye drops before each infusion and as prescribed for 72 hours after each infusion.

  • You should use vasoconstrictor eye drops right before each infusion.

  • You should use lubricating eye drops throughout treatment and for 30 days after your last dose of TIVDAK.

Do not wear contact lenses throughout your treatment with TIVDAK unless you are told to use them by your eye specialist.

What are the possible side effects of TIVDAK?

Serious side effects of TIVDAK may include:

Peripheral neuropathy (nerve problems) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you have new or worsening numbness or tingling in your hands or feet or muscle weakness.

Bleeding (hemorrhage) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you get signs or symptoms of bleeding during treatment with TIVDAK including blood in your stools or black stools (looks like tar), blood in your urine, cough up or vomit blood, unusual vaginal bleeding, any unusual or heavy bleeding.

Lung problems. TIVDAK may cause severe or life-threatening inflammation of the lungs that can lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, or cough.

The most common side effects of TIVDAK include:

  • Decreased red blood cell and white blood cell counts

  • Tiredness

  • Nausea

  • Numbness or tingling in your hands or feet, or muscle weakness (peripheral neuropathy)

  • Hair loss (alopecia)

  • Nosebleed (epistaxis)

  • Eye problems (conjunctival disorders)

  • Bleeding (hemorrhage)

  • Changes in kidney function blood tests

  • Dry eye

  • Abnormal blood clotting test results

  • Diarrhea

  • Rash

Your healthcare provider may decrease your dose of TIVDAK, temporarily stop, or completely stop treatment if you have side effects.

What should I tell my healthcare provider before receiving TIVDAK?

Tell your healthcare provider about all your medical conditions, including if you:

  • have a history of vision or eye problems

  • have numbness or tingling in your hands or feet

  • have bleeding problems

  • have liver problems

  • are pregnant or plan to become pregnant, TIVDAK can harm your unborn baby.

  • are breastfeeding (nursing) or plan to breastfeed. It is not known if TIVDAK passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of TIVDAK

    Females who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with TIVDAK.

    • You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of TIVDAK.

    Males with female partners who are able to become pregnant:

    • You should use effective birth control during treatment and for 4 months after the last dose of TIVDAK

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking TIVDAK with certain other medicines may cause side effects.

These are not all the possible side effects of TIVDAK. Discuss side effects with your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.

Please see Important Facts about TIVDAK including IMPORTANT WARNING.

What is TIVDAK®?

TIVDAK is a prescription medicine used to treat adults with cervical cancer:

  • that has returned or has spread to other parts of the body, and

  • who have received chemotherapy that did not work or is no longer working

TIVDAK was FDA-approved based on a clinical study that measured how many patients had a tumor response and how long that response lasted. Continued approval is dependent on the results of an ongoing study to confirm the benefit of TIVDAK.

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