Before you start Tivdak

Before your infusion appointment

Caring for your eyes is very important when starting treatment with Tivdak

Be sure to follow Tivdak Required Eye Care and talk to your care team if you have any questions.

Tivdak Required Eye Care may help reduce the risk of eye problems

Tivdak can cause serious side effects, including eye problems. Eye problems are common with Tivdak and can also be serious. Tivdak can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment with Tivdak.

Tivdak Required Eye Care At‐A‐Glance

  • Step 1

    Before infusion appointment

    • You will need to see an eye specialist to check your eyes before each treatment of Tivdak

  • Step 2

    During infusion appointment

    • You will apply steroid eye drops with the help of a nurse before your infusion

    • You will apply vasoconstrictor eye drops with the help of a nurse right before your infusion

    • Cold packs will be placed over your eyes

  • Step 3

    After infusion appointment

    • Continue to apply steroid eye drops for 2-3 days (72 hours) after each infusion, or as instructed by your care team

    • Apply lubricating eye drops throughout treatment and for 30 days after your last dose of Tivdak or as instructed by your care team

    • If you experience any new or worsening eye problems during treatment, tell your healthcare provider, you may need to visit an eye specialist

    • See an eye specialist for a slit lamp exam before filling or renewing your steroid eye drops prescription

Before your first infusion, you will need to see an eye specialist, which can be either an optometrist or an ophthalmologist. Both are trained to perform an eye exam.

Your healthcare provider will…

  • Send You to an Eye Specialist to Check Your Eyes to monitor any new or worsening signs or symptoms of eye problems. This will occur before your first treatment with Tivdak, before each dose of Tivdak, and as needed.
  • Prescribe 3 Different Types of Eye Drops before you start treatment with Tivdak to Help Reduce the Risk of Eye Problems. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider.

Meet your drops

  • Tivdak Vasoconstrictor Eye Drops Icon

    Vasoconstrictor drops

    May help reduce eye redness and discomfort(Nurse will assist during your infusion)

  • Tivdak Steroid Eye Drops Icon

    Steroid drops

    May help protect against swelling and itchiness(Nurse will assist during the infusion. You will also take drops after infusion)

  • Tivdak Lubricating Eye Drops Icon

    Lubricating drops

    May help protect against dryness(You will take throughout treatment)

Watch a step-by-step video on how to apply eye drops

Can I buy my eye drops over the counter?

You will be prescribed 3 different types of eye drops. The vasoconstrictor and steroid drops will need to be filled by a pharmacist. You can purchase the lubricating drops over the counter. If the lubricating eye drops your care team recommended are not in stock, ask your pharmacist to recommend another.

A few things to remember

General Reminders

  • On infusion day

    Tivdak Bring All 3 Drops Icon

    Bring all 3 eye drops

    Set a reminder or create a checklist for yourself. If you forget your drops, your infusion might get delayed. Use the Eye Drop Tracker to help you stay on top of your eye drop schedule.

  • Throughout treatment

    • Tivdak Avoid Contact Lenses Icon

      Avoid contact lenses

      Do not wear contact lenses throughout your treatment unless you are told to use them by your eye specialist.

    • Tivdak Avoid Eye Irritants Icon

      Avoid eye irritants

      Avoid applying anything near or on your eyes that may cause discomfort or irritation.

    • Tivdak Steroid Prescription Renewal Icon

      Steroid prescription renewal

      See an eye specialist for a slit lamp exam before your first prescription and before renewing your steroid eye drops prescription.

What happens if I forget my eye drops on the day of infusion?

Forgetting your drops could delay your treatment. Remember to keep track of your drops so you don't run out. The best thing to do is to remember to bring all of your drops to your infusion appointment. Try setting a reminder or creating a checklist for yourself on the day of your appointment to help you remember.

Throughout your treatment with Tivdak, avoid contact lenses unless advised by your eye specialist. Also avoid applying anything near or on your eyes that may cause discomfort or irritation.

At Your Infusion

The Infusion Appointment

Your care team will give you the infusion of Tivdak. They will also take some steps that may help reduce the risk of eye problems. During your appointment you can expect:

  • Tivdak Infusion Appointment Eye Drops Icon

    1. Eye Drops:

    Eye drops will be applied under a nurse’s supervision

    • Steroid—1 drop/eye before infusion or as instructed by your care team

    • Vasoconstrictor—3 drops/eye right before infusion or as instructed by your care team

  • Tivdak Infusion Appointment Cold Packs Icon

    2. Cold Packs:

    • A member of your care team will give you a cold pack to place over your eyes before, during, and after the infusion
    • Cold packs will be rotated and kept on starting ~10 minutes before your infusion until ~20 minutes after for a total of 60 minutes
  • Tivdak Infusion Appointment Infusion Icon

    3. Infusion:

    The infusion will last approximately 30 minutes

The full appointment may take more than an hour due to pre-infusion eye check and paperwork. Your doctor will work with you to decide how many treatments you will need.

After your infusion

Caring for your eyes after your infusion

Help maintain good eye health

Caring for your eyes between infusions is very important. If you follow Tivdak Required Eye Care, you may reduce the risk of eye problems.

Talk to your care team if you have any questions.

Apply your eye drops as directed

  • After your appointment on infusion day

    Steroid drops
    1 drop per eye, 2x during the remainder of infusion day or as instructed by your care team

  • Days 2-3 (72 hours) following your infusion

    Steroid drops

    • Day 2: 1 drop per eye, 3x a day or as instructed by your care team

    • Day 3: 1 drop per eye, 3x a day or as instructed by your care team

Ongoing

Lubricating drops
Use these drops for the duration of treatment and for 30 days after your last dose of Tivdak or as instructed by your care team.

Check your eyes daily

Be on the lookout for any eye problems, such as:

Tivdak Eye Problems Icon
  • Dry eyes

  • Eye redness

  • Eye irritation

  • Corneal ulcers

  • Blurred vision

  • Severe vision loss

What do I do if I experience any eye problems?

If you experience any new or worsening changes with your eyes or eye problems, call your care team. Your care team is there to help.

TivdakTexts is a text message support program designed to assist you throughout treatment

TivdakTexts Overview

Some benefits of TivdakTexts include:

  • TivdakTexts Appointment Reminders Icon

    Appointment Reminders

  • TivdakTexts Eye Drop Reminders Icon

    Eye Drop Reminders

To sign up for TivdakTexts, you should follow these steps:

  • Mobile Phone

    Step 1: On your mobile phone, text the word JOIN to 74277

  • Step 2: When you get a message back from us, text back AGREE to confirm your participation in the support program

  • Step 3: Then answer 3 questions:

    • Your first name so we can personalize messages

    • Your zip code so we can set your time zone

    • The date you started or plan to start taking Tivdak

  • Message and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP for help with the program. Text STOP to stop receiving messages. See Terms of Use and Conditions. By initiating a text message, you agree to receive automated text messages from Seagen. You can unsubscribe at any time. You represent that you are the subscriber of the number provided and 18 or older. You must notify Seagen immediately if you relinquish the number provided. Consent is not required as a condition of purchasing any products or services.

Helpful tools while taking Tivdak

  • Tivdak Eye Drop Tracker Icon
    Eye Drop Tracker

    A tracker to help you stay on top of your eye drop schedule.

    Download

Helpful Tivdak tools

Learn more

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about TIVDAK?

Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment.

Your healthcare provider will send you to an eye specialist to check your eyes before you start treatment with TIVDAK, before each dose of TIVDAK, and as needed for any new or worsening signs and symptoms of eye problems.

Your healthcare provider will prescribe 3 different types of eye drops before you start treatment with TIVDAK. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider to reduce your risk of eye problems:

  • You should use steroid eye drops before each infusion and as prescribed for 72 hours after each infusion.

  • You should use vasoconstrictor eye drops right before each infusion.

  • You should use lubricating eye drops throughout treatment and for 30 days after your last dose of TIVDAK.

Do not wear contact lenses throughout your treatment with TIVDAK unless you are told to use them by your eye specialist.

What are the possible side effects of TIVDAK?

Serious side effects of TIVDAK may include:

Peripheral neuropathy (nerve problems) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you have new or worsening numbness or tingling in your hands or feet or muscle weakness.

Bleeding (hemorrhage) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you get signs or symptoms of bleeding during treatment with TIVDAK including blood in your stools or black stools (looks like tar), blood in your urine, cough up or vomit blood, unusual vaginal bleeding, any unusual or heavy bleeding.

Lung problems. TIVDAK may cause severe or life-threatening inflammation of the lungs that can lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, or cough.

The most common side effects of TIVDAK include:

  • Decreased red blood cell and white blood cell counts

  • Tiredness

  • Nausea

  • Numbness or tingling in your hands or feet, or muscle weakness (peripheral neuropathy)

  • Hair loss (alopecia)

  • Nosebleed (epistaxis)

  • Eye problems (conjunctival disorders)

  • Bleeding (hemorrhage)

  • Changes in kidney function blood tests

  • Dry eye

  • Abnormal blood clotting test results

  • Diarrhea

  • Rash

Your healthcare provider may decrease your dose of TIVDAK, temporarily stop, or completely stop treatment if you have side effects.

What should I tell my healthcare provider before receiving TIVDAK?

Tell your healthcare provider about all your medical conditions, including if you:

  • have a history of vision or eye problems

  • have numbness or tingling in your hands or feet

  • have bleeding problems

  • have liver problems

  • are pregnant or plan to become pregnant, TIVDAK can harm your unborn baby.

  • are breastfeeding (nursing) or plan to breastfeed. It is not known if TIVDAK passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of TIVDAK

    Females who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with TIVDAK.

    • You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of TIVDAK.

    Males with female partners who are able to become pregnant:

    • You should use effective birth control during treatment and for 4 months after the last dose of TIVDAK

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking TIVDAK with certain other medicines may cause side effects.

These are not all the possible side effects of TIVDAK. Discuss side effects with your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.

Please see Important Facts about TIVDAK including IMPORTANT WARNING.

What is TIVDAK®?

TIVDAK is a prescription medicine used to treat adults with cervical cancer:

  • that has returned or has spread to other parts of the body, and

  • who have received chemotherapy that did not work or is no longer working

TIVDAK was FDA-approved based on a clinical study that measured how many patients had a tumor response and how long that response lasted. Continued approval is dependent on the results of an ongoing study to confirm the benefit of TIVDAK.

Important Safety Information

What is the most important information I should know about TIVDAK?

Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss.

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about TIVDAK?

Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment.

Your healthcare provider will send you to an eye specialist to check your eyes before you start treatment with TIVDAK, before each dose of TIVDAK, and as needed for any new or worsening signs and symptoms of eye problems.

Your healthcare provider will prescribe 3 different types of eye drops before you start treatment with TIVDAK. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider to reduce your risk of eye problems:

  • You should use steroid eye drops before each infusion and as prescribed for 72 hours after each infusion.

  • You should use vasoconstrictor eye drops right before each infusion.

  • You should use lubricating eye drops throughout treatment and for 30 days after your last dose of TIVDAK.

Do not wear contact lenses throughout your treatment with TIVDAK unless you are told to use them by your eye specialist.

What are the possible side effects of TIVDAK?

Serious side effects of TIVDAK may include:

Peripheral neuropathy (nerve problems) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you have new or worsening numbness or tingling in your hands or feet or muscle weakness.

Bleeding (hemorrhage) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you get signs or symptoms of bleeding during treatment with TIVDAK including blood in your stools or black stools (looks like tar), blood in your urine, cough up or vomit blood, unusual vaginal bleeding, any unusual or heavy bleeding.

Lung problems. TIVDAK may cause severe or life-threatening inflammation of the lungs that can lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, or cough.

The most common side effects of TIVDAK include:

  • Decreased red blood cell and white blood cell counts

  • Tiredness

  • Nausea

  • Numbness or tingling in your hands or feet, or muscle weakness (peripheral neuropathy)

  • Hair loss (alopecia)

  • Nosebleed (epistaxis)

  • Eye problems (conjunctival disorders)

  • Bleeding (hemorrhage)

  • Changes in kidney function blood tests

  • Dry eye

  • Abnormal blood clotting test results

  • Diarrhea

  • Rash

Your healthcare provider may decrease your dose of TIVDAK, temporarily stop, or completely stop treatment if you have side effects.

What should I tell my healthcare provider before receiving TIVDAK?

Tell your healthcare provider about all your medical conditions, including if you:

  • have a history of vision or eye problems

  • have numbness or tingling in your hands or feet

  • have bleeding problems

  • have liver problems

  • are pregnant or plan to become pregnant, TIVDAK can harm your unborn baby.

  • are breastfeeding (nursing) or plan to breastfeed. It is not known if TIVDAK passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of TIVDAK

    Females who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with TIVDAK.

    • You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of TIVDAK.

    Males with female partners who are able to become pregnant:

    • You should use effective birth control during treatment and for 4 months after the last dose of TIVDAK

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking TIVDAK with certain other medicines may cause side effects.

These are not all the possible side effects of TIVDAK. Discuss side effects with your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.

Please see Important Facts about TIVDAK including IMPORTANT WARNING.

What is TIVDAK®?

TIVDAK is a prescription medicine used to treat adults with cervical cancer:

  • that has returned or has spread to other parts of the body, and

  • who have received chemotherapy that did not work or is no longer working

TIVDAK was FDA-approved based on a clinical study that measured how many patients had a tumor response and how long that response lasted. Continued approval is dependent on the results of an ongoing study to confirm the benefit of TIVDAK.

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