Before infusion appointment
You will need to see an eye specialist to check your eyes before each treatment of Tivdak
What is TIVDAK®? TIVDAK is a prescription medicine used to treat adults with cervical cancer that has returned or has spread to other parts of the body, and who have received chemotherapy that did not work or is no longer working. TIVDAK was FDA-approved based on a clinical study that measured how many patients had a tumor response and how long that response lasted. Continued approval is dependent on the results of an ongoing study to confirm the benefit of TIVDAK.
This site is intended for US residents only.
Before you start Tivdak
Be sure to follow Tivdak Required Eye Care and talk to your care team if you have any questions.
Tivdak can cause serious side effects, including eye problems. Eye problems are common with Tivdak and can also be serious. Tivdak can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment with Tivdak.
Before infusion appointment
You will need to see an eye specialist to check your eyes before each treatment of Tivdak
During infusion appointment
You will apply steroid eye drops with the help of a nurse before your infusion
You will apply vasoconstrictor eye drops with the help of a nurse right before your infusion
Cold packs will be placed over your eyes
After infusion appointment
Continue to apply steroid eye drops for 2-3 days (72 hours) after each infusion, or as instructed by your care team
Apply lubricating eye drops throughout treatment and for 30 days after your last dose of Tivdak or as instructed by your care team
If you experience any new or worsening eye problems during treatment, tell your healthcare provider, you may need to visit an eye specialist
See an eye specialist for a slit lamp exam before filling or renewing your steroid eye drops prescription
Meet your drops
Vasoconstrictor drops
May help reduce eye redness and discomfort(Nurse will assist during your infusion)
Steroid drops
May help protect against swelling and itchiness(Nurse will assist during the infusion. You will also take drops after infusion)
Lubricating drops
May help protect against dryness(You will take throughout treatment)
Watch a step-by-step video on how to apply eye drops
You will be prescribed 3 different types of eye drops. The vasoconstrictor and steroid drops will need to be filled by a pharmacist. You can purchase the lubricating drops over the counter. If the lubricating eye drops your care team recommended are not in stock, ask your pharmacist to recommend another.
General Reminders
On infusion day
Bring all 3 eye drops
Set a reminder or create a checklist for yourself. If you forget your drops, your infusion might get delayed. Use the Eye Drop Tracker to help you stay on top of your eye drop schedule.
Throughout treatment
Avoid contact lenses
Do not wear contact lenses throughout your treatment unless you are told to use them by your eye specialist.
Avoid eye irritants
Avoid applying anything near or on your eyes that may cause discomfort or irritation.
Steroid prescription renewal
See an eye specialist for a slit lamp exam before your first prescription and before renewing your steroid eye drops prescription.
What happens if I forget my eye drops on the day of infusion?
Forgetting your drops could delay your treatment. Remember to keep track of your drops so you don't run out. The best thing to do is to remember to bring all of your drops to your infusion appointment. Try setting a reminder or creating a checklist for yourself on the day of your appointment to help you remember.
At Your Infusion
Your care team will give you the infusion of Tivdak. They will also take some steps that may help reduce the risk of eye problems. During your appointment you can expect:
1. Eye Drops:
Eye drops will be applied under a nurse’s supervision
Steroid—1 drop/eye before infusion or as instructed by your care team
Vasoconstrictor—3 drops/eye right before infusion or as instructed by your care team
2. Cold Packs:
3. Infusion:
The infusion will last approximately 30 minutes
The full appointment may take more than an hour due to pre-infusion eye check and paperwork. Your doctor will work with you to decide how many treatments you will need.
After your infusion
Caring for your eyes between infusions is very important. If you follow Tivdak Required Eye Care, you may reduce the risk of eye problems.
Talk to your care team if you have any questions.
Apply your eye drops as directed
After your appointment on infusion day
Steroid drops
1 drop per eye, 2x during the remainder of infusion day or as instructed by your care team
Days 2-3 (72 hours) following your infusion
Steroid drops
Day 2: 1 drop per eye, 3x a day or as instructed by your care team
Day 3: 1 drop per eye, 3x a day or as instructed by your care team
Ongoing
Lubricating drops
Use these drops for the duration of treatment and for 30 days after your last dose of Tivdak or as instructed by your care team.
Be on the lookout for any eye problems, such as:
Dry eyes
Eye redness
Eye irritation
Corneal ulcers
Blurred vision
Severe vision loss
If you experience any new or worsening changes with your eyes or eye problems, call your care team. Your care team is there to help.
TivdakTexts Overview
Some benefits of TivdakTexts include:
Appointment Reminders
Eye Drop Reminders
To sign up for TivdakTexts, you should follow these steps:
Step 1: On your mobile phone, text the word JOIN to 74277
Step 2: When you get a message back from us, text back AGREE to confirm your participation in the support program
Step 3: Then answer 3 questions:
Your first name so we can personalize messages
Your zip code so we can set your time zone
The date you started or plan to start taking Tivdak
Message and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP for help with the program. Text STOP to stop receiving messages. See Terms of Use and Conditions. By initiating a text message, you agree to receive automated text messages from Seagen. You can unsubscribe at any time. You represent that you are the subscriber of the number provided and 18 or older. You must notify Seagen immediately if you relinquish the number provided. Consent is not required as a condition of purchasing any products or services.
Helpful tools while taking Tivdak
Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment.
Your healthcare provider will send you to an eye specialist to check your eyes before you start treatment with TIVDAK, before each dose of TIVDAK, and as needed for any new or worsening signs and symptoms of eye problems.
Your healthcare provider will prescribe 3 different types of eye drops before you start treatment with TIVDAK. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider to reduce your risk of eye problems:
You should use steroid eye drops before each infusion and as prescribed for 72 hours after each infusion.
You should use vasoconstrictor eye drops right before each infusion.
You should use lubricating eye drops throughout treatment and for 30 days after your last dose of TIVDAK.
Do not wear contact lenses throughout your treatment with TIVDAK unless you are told to use them by your eye specialist.
Serious side effects of TIVDAK may include:
Peripheral neuropathy (nerve problems) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you have new or worsening numbness or tingling in your hands or feet or muscle weakness.
Bleeding (hemorrhage) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you get signs or symptoms of bleeding during treatment with TIVDAK including blood in your stools or black stools (looks like tar), blood in your urine, cough up or vomit blood, unusual vaginal bleeding, any unusual or heavy bleeding.
Lung problems. TIVDAK may cause severe or life-threatening inflammation of the lungs that can lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, or cough.
The most common side effects of TIVDAK include:
Decreased red blood cell and white blood cell counts
Tiredness
Nausea
Numbness or tingling in your hands or feet, or muscle weakness (peripheral neuropathy)
Hair loss (alopecia)
Nosebleed (epistaxis)
Eye problems (conjunctival disorders)
Bleeding (hemorrhage)
Changes in kidney function blood tests
Dry eye
Abnormal blood clotting test results
Diarrhea
Rash
Your healthcare provider may decrease your dose of TIVDAK, temporarily stop, or completely stop treatment if you have side effects.
Tell your healthcare provider about all your medical conditions, including if you:
have a history of vision or eye problems
have numbness or tingling in your hands or feet
have bleeding problems
have liver problems
are pregnant or plan to become pregnant, TIVDAK can harm your unborn baby.
are breastfeeding (nursing) or plan to breastfeed. It is not known if TIVDAK passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of TIVDAK
Females who are able to become pregnant:
Your healthcare provider should do a pregnancy test before you start treatment with TIVDAK.
You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of TIVDAK.
Males with female partners who are able to become pregnant:
You should use effective birth control during treatment and for 4 months after the last dose of TIVDAK
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking TIVDAK with certain other medicines may cause side effects.
These are not all the possible side effects of TIVDAK. Discuss side effects with your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.
Please see Important Facts about TIVDAK including IMPORTANT WARNING.
TIVDAK is a prescription medicine used to treat adults with cervical cancer:
that has returned or has spread to other parts of the body, and
who have received chemotherapy that did not work or is no longer working
TIVDAK was FDA-approved based on a clinical study that measured how many patients had a tumor response and how long that response lasted. Continued approval is dependent on the results of an ongoing study to confirm the benefit of TIVDAK.
What is the most important information I should know about TIVDAK?
Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss.
Eye problems are common with TIVDAK and can be serious. TIVDAK can cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye irritation, corneal ulcers, blurred vision, and severe vision loss. Tell your healthcare provider if you develop new or worsening vision changes or eye problems during treatment.
Your healthcare provider will send you to an eye specialist to check your eyes before you start treatment with TIVDAK, before each dose of TIVDAK, and as needed for any new or worsening signs and symptoms of eye problems.
Your healthcare provider will prescribe 3 different types of eye drops before you start treatment with TIVDAK. Bring the eye drops with you to each infusion and use them as directed by your healthcare provider to reduce your risk of eye problems:
You should use steroid eye drops before each infusion and as prescribed for 72 hours after each infusion.
You should use vasoconstrictor eye drops right before each infusion.
You should use lubricating eye drops throughout treatment and for 30 days after your last dose of TIVDAK.
Do not wear contact lenses throughout your treatment with TIVDAK unless you are told to use them by your eye specialist.
Serious side effects of TIVDAK may include:
Peripheral neuropathy (nerve problems) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you have new or worsening numbness or tingling in your hands or feet or muscle weakness.
Bleeding (hemorrhage) are common with TIVDAK and can be serious. Tell your healthcare provider right away if you get signs or symptoms of bleeding during treatment with TIVDAK including blood in your stools or black stools (looks like tar), blood in your urine, cough up or vomit blood, unusual vaginal bleeding, any unusual or heavy bleeding.
Lung problems. TIVDAK may cause severe or life-threatening inflammation of the lungs that can lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, or cough.
The most common side effects of TIVDAK include:
Decreased red blood cell and white blood cell counts
Tiredness
Nausea
Numbness or tingling in your hands or feet, or muscle weakness (peripheral neuropathy)
Hair loss (alopecia)
Nosebleed (epistaxis)
Eye problems (conjunctival disorders)
Bleeding (hemorrhage)
Changes in kidney function blood tests
Dry eye
Abnormal blood clotting test results
Diarrhea
Rash
Your healthcare provider may decrease your dose of TIVDAK, temporarily stop, or completely stop treatment if you have side effects.
Tell your healthcare provider about all your medical conditions, including if you:
have a history of vision or eye problems
have numbness or tingling in your hands or feet
have bleeding problems
have liver problems
are pregnant or plan to become pregnant, TIVDAK can harm your unborn baby.
are breastfeeding (nursing) or plan to breastfeed. It is not known if TIVDAK passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of TIVDAK
Females who are able to become pregnant:
Your healthcare provider should do a pregnancy test before you start treatment with TIVDAK.
You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of TIVDAK.
Males with female partners who are able to become pregnant:
You should use effective birth control during treatment and for 4 months after the last dose of TIVDAK
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking TIVDAK with certain other medicines may cause side effects.
These are not all the possible side effects of TIVDAK. Discuss side effects with your healthcare provider. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.
Please see Important Facts about TIVDAK including IMPORTANT WARNING.
TIVDAK is a prescription medicine used to treat adults with cervical cancer:
that has returned or has spread to other parts of the body, and
who have received chemotherapy that did not work or is no longer working
TIVDAK was FDA-approved based on a clinical study that measured how many patients had a tumor response and how long that response lasted. Continued approval is dependent on the results of an ongoing study to confirm the benefit of TIVDAK.