Important Safety Information
What is the most important information I should know about TIVDAK?
Eye problems are common with TIVDAK and can be severe. TIVDAK can
cause changes to the surface of your eye that can lead to dry eyes, eye redness, eye
irritation, corneal ulcers, blurred vision, and severe vision loss. Tell
your healthcare provider if you develop new or worsening vision changes or eye problems
during treatment.
Your healthcare provider will send you to an eye specialist to check your eyes before you
start treatment with TIVDAK, before each infusion for your first 9 infusions of TIVDAK, and
as needed for any new or worsening signs or symptoms of eye problems. Your healthcare
provider will ask if you have any signs or symptoms of eye problems before each infusion.
You will be referred to an eye specialist for any new or worsening signs or symptoms of eye
problems.
Your healthcare provider will prescribe 3 different types of eye drops before you start
treatment with TIVDAK. Bring the eye drops with you to each infusion and
use them as directed by your healthcare provider to reduce your risk of eye
problems:
- Use 1 drop of steroid eye drops in each eye before each infusion and continue to use
your eye drops 3 times a day for 3 days after each infusion
- Use vasoconstrictor eye drops right before each infusion
- Use lubricating eye drops throughout treatment and for 30 days after your last dose of
TIVDAK
Do not wear contact lenses throughout your treatment with TIVDAK
unless you are told to use them by your eye specialist.
What are the possible side effects of TIVDAK?
Serious side effects of TIVDAK may include:
Eye problems. See “What is the most important
information I should know about TIVDAK?”
Nerve problems (peripheral neuropathy) are common with TIVDAK and
can be serious. Tell your healthcare provider right away if you have new or worsening
numbness or tingling in your hands or feet or muscle weakness.
Bleeding problems (hemorrhage) are common with TIVDAK and can be
serious. Tell your healthcare provider or get medical help right away if you have signs or
symptoms of bleeding during treatment with TIVDAK, including blood in your stools or black
stools (looks like tar), blood in your urine, cough up or vomit blood, unusual vaginal
bleeding, or any unusual or heavy bleeding.
Lung problems. TIVDAK may cause severe or life-threatening
inflammation of the lungs that can lead to death. Tell your healthcare provider right away
if you have new or worsening symptoms, including trouble breathing, shortness of breath, or
cough.
Severe skin reactions. TIVDAK may cause severe or life-threatening
skin reactions that can lead to death. Tell your healthcare provider or get medical help
right away if you have signs or symptoms of a severe skin reaction during treatment with
TIVDAK, including:
- Skin reactions that look like rings (target lesions)
- Rash or itching that continues to get worse
- Blistering or peeling of the skin
- Painful sores or ulcers in your mouth, nose, throat, or genital area
- Fever or flu-like symptoms
- Swollen lymph nodes
The most common side effects of TIVDAK include:
- Decreased red blood cell counts
- Numbness or tingling in your hands or feet
- Eye problems (conjunctival disorders)
- Nausea
- Tiredness
- Changes in liver function blood tests
- Nosebleed
- Hair loss (alopecia)
- Bleeding (hemorrhage)
Your healthcare provider may decrease your dose of TIVDAK, temporarily stop, or completely
stop treatment if you have side effects.
What should I tell my healthcare provider before receiving TIVDAK?
Tell your healthcare provider about all your medical conditions, including
if you:
- have a history of vision or eye problems
- have numbness or tingling in your hands or feet
- have bleeding problems
- have liver problems
- are pregnant or plan to become pregnant; TIVDAK can harm your unborn baby. Tell your
healthcare provider right away if you become pregnant or think you may be pregnant
during treatment with TIVDAK
-
are breastfeeding (nursing) or plan to breastfeed. It is not known if TIVDAK passes
into your breast milk. Do not breastfeed during treatment and for at least 3 weeks
after the last dose of TIVDAK
Females who can become pregnant:
- Your healthcare provider should do a pregnancy test before you start treatment
with TIVDAK
- Use an effective method of birth control during your treatment and for at least
2 months after the last dose of TIVDAK
Males with female partners who can become pregnant:
- Use effective birth control during treatment and for 4 months after the last
dose of TIVDAK
Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Taking TIVDAK with certain other medicines may cause side effects.
These are not all of the possible side effects of TIVDAK. Discuss side effects with your
healthcare provider. You may report side effects to FDA at 1-800-FDA-1088.
Please see the full Prescribing
Information with Medication
Guide about TIVDAK including an IMPORTANT WARNING.
